Cell division promotes efficient retrotransposition in a stable L1 reporter cell line.

ABSTRACT:

Background

Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) complex, which must enter the nucleus before retrotransposition can proceed. Thus, the nuclear import of L1 RNP presents an opportunity for cells to regulate L1 retrotransposition post-translationally. The effect of cell division on L1 retrotransposition has been investigated by two previous studies, which observed varied degrees of inhibition in retrotransposition when primary cell strains or cancer cell lines were experimentally arrested in different stages of the cell cycle. However, seemingly divergent conclusions were reached. The role of cell division on retrotr

SUBMITTER: Xie Y 

PROVIDER: S-EPMC3607998 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature