Profiling and metaanalysis of epidermal keratinocytes responses to epidermal growth factor.

ABSTRACT:

Background

One challenge of systems biology is the integration of new data into the preexisting, and then re-interpretation of the integrated data. Here we use readily available metaanalysis computational methods to integrate new data on the transcriptomic effects of EGF in primary human epidermal keratinocytes with preexisting transcriptomics data in keratinocytes and in EGF-treated non-epidermal cell types.

Results

We find that EGF promotes keratinocyte proliferation, attachment and motility and, surprisingly, induces DUSPs that attenuate the EGF signal. Our metaanalysis identified overlapping effects of EGF with those of IL-1 and IFNγ, activators of keratinocyte in inflammation and wound healing. We also identified the genes and pathways suppressed by EGF but induced by a

SUBMITTER: Blumenberg M 

PROVIDER: S-EPMC3608085 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature