Effects of botulinum toxin-induced paralysis on postnatal development of the supraspinatus muscle.

ABSTRACT: The mechanical environment plays an important role in musculoskeletal tissue development. The present study characterized changes in supraspinatus muscle due to removal of mechanical cues during postnatal development. An intramuscular injection of botulinum toxin type A (BTX) was used to induce and maintain paralysis in the left shoulders of mice since birth while the right shoulders received saline and served as contralateral controls. A separate group of animals was allowed to develop normally without any injections. Muscles were examined postnatally at various time points. The maximum isometric tetanic force generated by the muscle was significantly reduced in the BTX group compared to saline and normal groups. The paralyzed muscles were smaller and showed significant muscle atrophy and

SUBMITTER: Das R 

PROVIDER: S-EPMC3608102 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature