Antihypertensive therapy and cerebral hemodynamics in executive mild cognitive impairment: results of a pilot randomized clinical trial.

ABSTRACT:

Objectives

To compare the effects of three antihypertensive medications on cerebral hemodynamic and cognitive function in hypertensive individuals with executive dysfunction.

Design

Double-blind randomized clinical trial.

Setting

Community.

Participants

Fifty-three individuals aged 60 and older with hypertension and executive dysfunction.

Intervention

Lisinopril, candesartan, or hydrochlorothiazide for 1 year.

Measurements

Cerebral blood flow velocity (BFV; transcranial Doppler ultrasonography during rest, sitting, standing, hypercapnia, and hypocapnia), cognition, and blood pressure were measured at baseline and after 6 and 12 months. Linear mixed models were used to compare the three groups.

Results

Of the 53 participants, 47 had successf

SUBMITTER: Hajjar I 

PROVIDER: S-EPMC3608194 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature