Polymerization of a peptide-based enzyme substrate.

ABSTRACT: Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates.

SUBMITTER: Hahn ME 

PROVIDER: S-EPMC3608426 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature