Multiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.

ABSTRACT: Despite a long history of investigation, many bacteria associated with the human oral cavity have yet to be cultured. Studies that correlate the presence or abundance of uncultured species with oral health or disease highlight the importance of these community members. Thus, we sequenced several single-cell genomic amplicons from Desulfobulbus and Desulfovibrio (class Deltaproteobacteria) to better understand their function within the human oral community and their association with periodontitis, as well as other systemic diseases. Genomic data from oral Desulfobulbus and Desulfovibrio species were compared to other available deltaproteobacterial genomes, including from a subset of host-associated species. While both groups share a large number of genes with other environmental Deltaproteo

SUBMITTER: Campbell AG 

PROVIDER: S-EPMC3608642 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature