Pilot randomized trial of bupropion for adolescent methamphetamine abuse/dependence.

ABSTRACT:

Purpose

To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents.

Methods

Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling.

Results

Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo (p = .043) and males (p = .005) respectively.

Conclusions

Results do not support the feasibility of additional trials of bupropion for adole

SUBMITTER: Heinzerling KG 

PROVIDER: S-EPMC3608805 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature