Characterization of hairless (Hr) and FGF5 genes provides insights into the molecular basis of hair loss in cetaceans.

ABSTRACT:

Background

Hair is one of the main distinguishing characteristics of mammals and it has many important biological functions. Cetaceans originated from terrestrial mammals and they have evolved a series of adaptations to aquatic environments, which are of evolutionary significance. However, the molecular mechanisms underlying their aquatic adaptations have not been well explored. This study provided insights into the evolution of hair loss during the transition from land to water by investigating and comparing two essential regulators of hair follicle development and hair follicle cycling, i.e., the Hairless (Hr) and FGF5 genes, in representative cetaceans and their terrestrial relatives.

Results

The full open reading frame sequences of the Hr and FGF5 genes were characterize

SUBMITTER: Chen Z 

PROVIDER: S-EPMC3608953 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature