Transcriptional instability during evolving sepsis may limit biomarker based risk stratification.

ABSTRACT:

Background

Sepsis causes extensive morbidity and mortality in children worldwide. Prompt recognition and timely treatment of sepsis is critical in reducing morbidity and mortality. Genomic approaches are used to discover novel pathways, therapeutic targets and biomarkers. These may facilitate diagnosis and risk stratification to tailor treatment strategies.

Objective

To investigate the temporal gene expression during the evolution of sepsis induced multi-organ failure in response to a single organism, Neisseria meningitidis, in previously healthy children.

Method

RNA was extracted from serial blood samples (6 time points over 48 hours from presentation) from five critically ill children with meningococcal sepsis. Extracted RNA was hybridized to Affymetrix arrays. The

SUBMITTER: Kwan A 

PROVIDER: S-EPMC3609793 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature