Rs12512631 on the group specific complement (vitamin D-binding protein GC) implicated in melanoma susceptibility.

ABSTRACT:

Background

Solar radiation should be avoided in melanoma patients. Nevertheless, this is the main means by which the body produces vitamin D. Evidence suggests a protective role against cancer for vitamin D. Since vitamin D performs its function by binding the receptor encoded by the vitamin D-receptor gene (VDR), most studies have focused on polymorphisms (SNPs) within this gene. However, the gene encoding the vitamin D-binding protein (GC) appears in recent studies as a major player in the role of a serum vitamin D level regulator and in Cutaneous Melanoma (CM) predisposition.

Methods

We performed a case-control study of 12 polymorphisms on GC and 9 on VDR among 530 cases and 314 controls from Spanish population.

Results

We found association between SNP rs12512631,

SUBMITTER: Pena-Chilet M 

PROVIDER: S-EPMC3609832 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature