Androgen inhibits abdominal fat accumulation and negatively regulates the PCK1 gene in male chickens.

ABSTRACT: Capons are male chickens whose testes have been surgically incised. Capons show a significant increase in fat accumulation compared to intact male chickens. However, while caponization leads to a significant reduction in androgen levels in roosters, little is known about the molecular mechanisms through which androgen status affects lipogenesis in avian species. Therefore, investigation of the influence of androgens on fat accumulation in the chicken will provide insights into this process. In this study, Affymetrix microarray technology was used to analyze the gene expression profiles of livers from capons and intact male chickens because the liver is the major site of lipogenesis in avian species. Through gene ontology, we found that genes involved in hepatic lipogenic biosynthesis were

SUBMITTER: Duan J 

PROVIDER: S-EPMC3609855 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature