Replication and further characterization of a Type 1 diabetes-associated locus at the telomeric end of the major histocompatibility complex.

ABSTRACT:

Background

We recently reported an association between Type 1 diabetes and the telomeric major histocompatibility complex (MHC) single nucleotide polymorphism (SNP) rs1233478. As further families have been analyzed in the Type 1 Diabetes Genetics Consortium (T1DGC), we tested replication of the association and, with more data, analyzed haplotypic associations.

Methods

An additional 2717 case and 1315 control chromosomes have been analyzed from the T1DGC, with human leukocyte antigen (HLA) typing and data for 2837 SNPs across the MHC region.

Results

We confirmed the association of rs1233478 (new data only: P=2.2E-5, OR=1.4). We also found two additional SNPs nearby that were significantly associated with Type 1 diabetes (new data only rs3131020: P=8.3E-9, OR=0.65; rs15

SUBMITTER: Baschal EE 

PROVIDER: S-EPMC3610173 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature