Correlation of tumor-associated macrophages and clinicopathological factors in Wilms tumor.

ABSTRACT:

Background/purpose

Despite high long-term survival rates in patients with Wilms tumor, there is a need to develop better prognostic biomarkers in order to maximize cure while avoiding treatment-associated morbidities. Tumor-associated macrophages have been recently associated with poorer prognosis and increased disease progression in a number of adult cancers. We investigated the relationship between macrophages and clinicopathological fators in this pediatric solid tumor.

Methods

Tissue microarray sections of 124 Wilms tumor cases obtained from the Cooperative Human Tissue Network were stained with CD68, a macrophage marker using standard immunohistochemical techniques and quantified using digital image processing techniques. Macrophage densities were correlated by tumor st

SUBMITTER: Liou P 

PROVIDER: S-EPMC3610208 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature