A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

ABSTRACT:

Background

The complexity of the skeletal muscle and the identification of numerous human disease-causing mutations in its constitutive proteins make it an interesting tissue for proteomic studies aimed at understanding functional relationships of interacting proteins in both health and diseases.

Method

We undertook a large-scale study using two-hybrid screens and a human skeletal-muscle cDNA library to establish a proteome-scale map of protein-protein interactions centered on proteins involved in limb-girdle muscular dystrophies (LGMD). LGMD is a group of more than 20 different neuromuscular disorders that principally affect the proximal pelvic and shoulder girdle muscles.

Results and conclusion

The interaction network we unraveled incorporates 1018 proteins connecte

SUBMITTER: Blandin G 

PROVIDER: S-EPMC3610214 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature