TGFβ signaling regulates lipogenesis in human sebaceous glands cells.

ABSTRACT:

Background

Sebaceous glands are components of the skin essential for its normal lubrication by the production of sebum. This contributes to skin health and more importantly is crucial for the skin barrier function. A mechanistic understanding of sebaceous gland cells growth and differentiation has lagged behind that for keratinocytes, partly because of a lack of an in vitro model that can be used for experimental manipulation.

Methods

We have developed an in vitro culture model to isolate and grow primary human sebocytes without transformation that display functional characteristics of sebocytes. We used this novel method to probe the effect of Transforming Growth Factor β (TGFβ) signaling on sebocyte differentiation, by examining the expression of genes involved in lipogene

SUBMITTER: McNairn AJ 

PROVIDER: S-EPMC3610216 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature