Significantly fewer protein functional changing variants for lipid metabolism in Africans than in Europeans.

ABSTRACT:

Background

The disorders in metabolism of energy substances are usually related to some diseases, such as obesity, diabetes and cancer, etc. However, the genetic background for these disorders has not been well understood. In this study, we explored the genetic risk differences among human populations in metabolism (catabolism and biosynthesis) of energy substances, including lipids, carbohydrates and amino acids.

Results

Two genotype datasets (Hapmap and 1000 Genome) were used for this study. The genetic risks of protein functional changing variants (PFCVs) on genes involved in lipid, carbohydrate and amino acid metabolism were calculated using two genetic risk indices: the total number of PFCVs (Num) and the total possibly harmful score of PFCVs (R). Observations in these

SUBMITTER: Xue C 

PROVIDER: S-EPMC3610238 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature