LINE-1 and Alu hypomethylation in mucoepidermoid carcinoma.

ABSTRACT:

Background

Mucoepidermoid carcinoma (MEC) can be classified into low-, intermediate-, and high-grade tumors based on its histological features. MEC is mainly composed of three cell types (squamous or epidermoid, mucous and intermediate cells), which correlates with the histological grade and reflects its clinical behavior. Most cancers exhibit reduced methylation of repetitive sequences such as Long INterspersed Element-1 (LINE-1) and Alu elements. However, to date very little information is available on the LINE-1 and Alu methylation status in MEC. The aim of this study was to investigate LINE-1 and Alu element methylation in MEC and compare if key differences in the methylation status exist between the three different cell types, and adjacent normal salivary gland cells, to see i

SUBMITTER: Sirivanichsuntorn P 

PROVIDER: S-EPMC3610265 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature