Monocyte chemoattractant protein-1 promoter polymorphism and plasma levels in alzheimer's disease.

ABSTRACT:

Background

Neurodegenerative disorders such Alzheimer's disease (AD) are often characterized by senile plaques and neurofibrillary tangle. In addition, reactive astrogliosis, microglia activation and a chronic inflammation are found in AD brain. Activated microglia has been reported to express a large number of beta chemokines including monocyte chemoattractant protein-1 (MCP-1). The potential role of MCP-1 in AD pathogenesis is supported by the over expression of MCP-1 associated with an increase of amyloid deposition in transgenic mice. MCP-1 protein may be regulated by a single nucleotide polymorphism (SNP) occurring at position -2518 of the MCP-1 gene promoter. In this paper we correlated the A-2518G MCP-1 SNP distribution in three different populations: AD, control and MCI (mi

SUBMITTER: Porcellini E 

PROVIDER: S-EPMC3610278 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature