Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study.

ABSTRACT:

Objective

The trajectory of cognitive decline in patients with late-onset Alzheimer's disease varies widely. Genetic variations in CLU, PICALM, and CR1 are associated with Alzheimer's disease, but it is unknown whether they exert their effects by altering cognitive trajectory in elderly individuals at risk for the disease.

Method

The authors developed a Bayesian model to fit cognitive trajectories in a cohort of elderly subjects and test for genetic effects. They first validated the model's ability to detect the previously established effects of APOE ε4 alleles on age at cognitive decline and of psychosis on the rate of cognitive decline in 802 subjects from the Cardiovascular Health Cognition Study who did not have dementia at study entry and developed incident dementia dur

SUBMITTER: Sweet RA 

PROVIDER: S-EPMC3610571 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature