Revascularization of ischemic skeletal muscle by estrogen-related receptor-γ.

ABSTRACT:

Rationale

Oxidative myofibers in the skeletal muscles express high levels of angiogenic factors, have dense vasculature, and promptly revascularize during ischemia. Estrogen-related receptor-gamma (ERRγ) activates genes that govern metabolic and vascular features typical to oxidative myofibers. Therefore, ERRγ-dependent remodeling of the myofibers may promote neoangiogenesis and restoration of blood perfusion in skeletal muscle ischemia.

Objective

To investigate the muscle fiber type remodeling by ERRγ and its role in the vascular recovery of ischemic muscle.

Methods and results

Using immunohistology, we show that skeletal muscle-specific transgenic overexpression of ERRγ increases the proportions of oxidative and densely vascularized type IIA and IIX myofibers and de

SUBMITTER: Matsakas A 

PROVIDER: S-EPMC3610573 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature