Energy expenditure in obese children with pseudohypoparathyroidism type 1a.

ABSTRACT:

Context

Patients with pseudohypoparathyroidism type 1a (PHP-1a) develop early-onset obesity. The abnormality in energy expenditure and/or energy intake responsible for this weight gain is unknown.

Objective

The aim of this study was to evaluate energy expenditure in children with PHP-1a compared with obese controls.

Patients

We studied 6 obese females with PHP-1a and 17 obese female controls. Patients were recruited from a single academic center.

Measurements

Resting energy expenditure (REE) and thermogenic effect of a high fat meal were measured using whole room indirect calorimetry. Body composition was assessed using whole body dual energy x-ray absorptiometry. Fasting glucose, insulin, and hemoglobin A1C were measured.

Results

Children with PHP-1a ha

SUBMITTER: Shoemaker AH 

PROVIDER: S-EPMC3610772 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature