Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders.

ABSTRACT: Evidence implicates environmental factors in the pathogenesis of Autism Spectrum Disorders (ASD). However, the identity of specific environmental chemicals that influence ASD risk, severity or treatment outcome remains elusive. The impact of any given environmental exposure likely varies across a population according to individual genetic substrates, and this increases the difficulty of identifying clear associations between exposure and ASD diagnoses. Heritable genetic vulnerabilities may amplify adverse effects triggered by environmental exposures if genetic and environmental factors converge to dysregulate the same signaling systems at critical times of development. Thus, one strategy for identifying environmental risk factors for ASD is to screen for environmental factors that modulate

SUBMITTER: Stamou M 

PROVIDER: S-EPMC3610799 | biostudies-literature | 2013 Mar-Apr

REPOSITORIES: biostudies-literature