Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.

ABSTRACT:

Background

Alcohol and nicotine codependence can be considered as a more severe subtype of alcohol dependence. A portion of its risk may be attributable to genetic factors.

Methods

We searched for significant risk genomic regions specific for this disorder using a genome-wide association study. A total of 8,847 subjects underwent gene-disease association analysis, including (i) a discovery cohort of 818 European American cases with alcohol and nicotine codependence and 1,396 European American controls, (ii) a replication cohort of 5,704 Australian family subjects with 907 affected offspring, and (iii) a replication cohort of 449 African American cases and 480 African American controls. Additionally, a total of 38,714 subjects of European or African descent in 18 independent

SUBMITTER: Zuo L 

PROVIDER: S-EPMC3610804 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature