S-Glutathionylation of hepatic and visceral adipose proteins decreases in obese rats.

ABSTRACT:

Unlabelled

A number of clinical and biochemical studies demonstrate that obesity and insulin resistance are associated with increases in oxidative stress and inflammation. Paradoxically, insulin sensitivity can be enhanced by oxidative inactivation of cysteine residues of phosphatases, and inflammation can be reduced by S-glutathionylation with formation of protein-glutathione mixed disulfides (PSSG). Although oxidation of protein-bound thiols (PSH) is increased in multiple diseases, it is not known whether there are changes in PSH oxidation species in obesity.

Objective

In this work, the hypothesis that obesity is associated with decreased levels of proteins containing oxidized protein thiols was tested.

Design and methods

The tissue levels of protein sulfenic acids

SUBMITTER: Picklo MJ 

PROVIDER: S-EPMC3610808 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature