Effects of nanostructures and mouse embryonic stem cells on in vitro morphogenesis of rat testicular cords.

ABSTRACT: Morphogenesis of tubular structures is a common event during embryonic development. The signals providing cells with topographical cues to define a cord axis and to form new compartments surrounded by a basement membrane are poorly understood. Male gonadal differentiation is a late event during organogenesis and continues into postnatal life. The cellular changes resemble the mechanisms during embryonic life leading to tubular structures in other organs. Testicular cord formation is dependent on and first recognized by SRY-dependent aggregation of Sertoli cells leading to the appearance of testis-specific cord-like structures. Here we explored whether testicular cells use topographical cues in the form of nanostructures to direct or stimulate cord formation and whether embryonic stem cells

SUBMITTER: Pan F 

PROVIDER: S-EPMC3610873 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature