Gastrin-induced proliferation involves MEK partner 1 (MP1).
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ABSTRACT:
SUBMITTER: Steigedal TS
PROVIDER: S-EPMC3611038 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Gastrin-induced proliferation involves MEK partner 1 (MP1).
Steigedal Tonje S TS Prestvik Wenche S WS Selvik Linn-Karina M LK Fjeldbo Christina S CS Bruland Torunn T Lægreid Astrid A Thommesen Liv L
In vitro cellular & developmental biology. Animal 20130214 3
The peptide hormone gastrin is an important factor for the maintenance and homeostasis of the gastric mucosa. We show that gastrin stimulates proliferation in a dose-dependent manner in the human gastric adenocarcinoma cell line AGS-GR. Furthermore, we demonstrate that the MAPK scaffold protein MEK partner 1 (MP1) is important for gastrin-induced phosphorylation of ERK1 and ERK2 and that MP1 promotes gastrin-induced proliferation of AGS-GR cells. Our results suggest a role of MP1 in gastrin-indu ...[more]
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