Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis.

ABSTRACT:

Background

Several recent studies have provided evidence that polymorphisms in the telomerase reverse transcriptase (TERT) gene sequence are associated with cancer development, but a comprehensive synopsis is not available. We conducted a systematic review and meta-analysis of the available molecular epidemiology data regarding the association between TERT locus polymorphisms and predisposition to cancer.

Methods

A systematic review of the English literature was conducted by searching PubMed, Embase, Cancerlit, Google Scholar, and ISI Web of Knowledge databases for studies on associations between TERT locus polymorphisms and cancer risk. Random-effects meta-analysis was performed to pool per-allele odds ratios for TERT locus polymorphisms and risk of cancer, and between-stud

SUBMITTER: Mocellin S 

PROVIDER: S-EPMC3611810 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature