Hemochromatosis gene and nonalcoholic fatty liver disease: a systematic review and meta-analysis.

ABSTRACT:

Background & aims

Previous studies examining the relationship between the C282Y and H63D HFE mutations and presence of nonalcoholic fatty liver disease (NAFLD) have yielded conflicting results. The goal of this study was to systematically evaluate and summarize data on the association between these two variants and the presence of NAFLD.

Methods

The authors searched EMBASE and PUBMED from August 1, 1996 to August 12, 2010. Two investigators independently conducted data abstraction. Ethnic specific weighted prevalence was calculated and pooled odds ratios were estimated using the random effects model.

Results

From 2542 references, the authors included 16 case-control studies and 14 case-only studies, or 2610 cases and 7298 controls. The majority of the studies came fro

SUBMITTER: Hernaez R 

PROVIDER: S-EPMC3611963 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature