A polymorphism (rs2295080) in mTOR promoter region and its association with gastric cancer in a Chinese population.

ABSTRACT:

Background

As an imperative part of PI3K/Akt/mTOR pathway, mammalian target of rapamycin (mTOR) has been demonstrated to increase in gastric cancer cells and tumors. Our research explored the relationship between single nucleotide polymorphism (SNP) rs2295080 in mTOR promoter region and the risk of gastric cancer (GC).

Methods

Seven hundred and fifty-three (753) gastric adenocarcinoma patients and 854 matched healthy subjects were recruited in the cancer association study and 60 tissues were used to test the expression of mTOR. Unconditional logistic regression was selected to evaluate the association between the rs2295080 T>G polymorphism and GC risk. We then examined the functionality of this promoter genetic variant by luciferase assay and EMSA.

Results

Individuals

SUBMITTER: Xu M 

PROVIDER: S-EPMC3612103 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature