Pleiotropy and pathway analyses of genetic variants associated with both type 2 diabetes and prostate cancer.

ABSTRACT:

Aims

Epidemiological evidence shows that diabetes is associated with a reduced risk of prostate cancer. The objective of this study was to identify genes that may contribute to both type 2 diabetes and prostate cancer outcomes and the biological pathways these diseases may share.

Methods

The Atherosclerosis Risk in Communities (ARIC) Study is a population-based prospective cohort study in four U.S. communities that included a baseline examination in 1987-89 and three follow-up exams at three year intervals. Participants were 45-64 years old at baseline. We conducted a genomewide association (GWA) study of incident type 2 diabetes in males, summarized variation across genetic loci into a polygenic risk score, and determined if that diabetes risk score was also associated with

SUBMITTER: Raynor LA 

PROVIDER: S-EPMC3612454 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature