Prefrontal lactate predicts exercise-induced cognitive dysfunction in Gulf War Illness.

ABSTRACT:

Background

25% to 30% of Veterans deployed to the 1990 to 1991 Persian Gulf War exhibit an idiopathic syndrome of chronic fatigue, exertional exhaustion, pain, hyperalgesia, cognitive and affective dysfunction known as Gulf War Illness (GWI).

Methods

Gulf War veterans (n=15) and sedentary veteran and civilian controls (n=11) completed a 2-back working memory test in an fMRI before and after two bicycle exercise stress test. We performed single voxel (1)H MRS to evaluate brain metabolic differences in the left anterior cingulate cortex and the changes associated with exercise.

Results

Eight GWI subjects increased their 2-back scores after exercise (labelled increasers) and seven GWI subjects decreased their 2-back scores after exercise (labelled decreasers). These phen

SUBMITTER: Rayhan RU 

PROVIDER: S-EPMC3612516 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature