Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.

ABSTRACT: Metastasis confronts clinicians with two major challenges: estimating the patient's risk of metastasis and identifying therapeutic targets. Because they are key signal integrators connecting cellular processes to clinical outcome, we aimed to identify transcriptional nodes regulating cancer cell metastasis. Using rodent xenograft models that we previously developed, we identified the transcription factor Fos-related antigen-1 (Fra-1) as a key coordinator of metastasis. Because Fra-1 often is overexpressed in human metastatic breast cancers and has been shown to control their invasive potential in vitro, we aimed to assess the implication and prognostic significance of the Fra-1-dependent genetic program in breast cancer metastasis and to identify potential Fra-1-dependent therapeutic targe

SUBMITTER: Desmet CJ 

PROVIDER: S-EPMC3612632 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature