Ontology highlight
ABSTRACT:
SUBMITTER: Nagata KO
PROVIDER: S-EPMC3612634 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Nagata Koh O KO Nakada Chieko C Kasai Rinshi S RS Kusumi Akihiro A Ueda Kazumitsu K
Proceedings of the National Academy of Sciences of the United States of America 20130311 13
The generation of high-density lipoprotein (HDL), one of the most critical events for preventing atherosclerosis, is mediated by ATP-binding cassette protein A1 (ABCA1). ABCA1 is known to transfer cellular cholesterol and phospholipids to apolipoprotein A-I (apoA-I) for generating discoidal HDL (dHDL) particles, composed of 100-200 lipid molecules surrounded by two apoA-I molecules; however, the regulatory mechanisms are still poorly understood. Here we observed ABCA1-GFP and apoA-I at the level ...[more]