Stem cell-derived endothelial cells for cardiovascular disease: a therapeutic perspective.

ABSTRACT: Stem cell therapy and organ regeneration are therapeutic approaches that will, we suggest, become mainstream for the treatment of human disease. Endothelial cells, which line the luminal surface of every vessel in the body, are essential components in any organ regeneration programme. There are a number of potentially therapeutic endothelial cell types, including embryonic, adult progenitor and induced pluripotent stem cell-derived endothelial cells, as well as host vascular cells. The features (benefits as well as disadvantages) of each cell type that make them potentially useful in therapy are important to consider. The field of stem cell biology is well developed in terms of protocols for generating endothelium. However, where there is a distinct and urgent unmet need for knowledge conc

SUBMITTER: Reed DM 

PROVIDER: S-EPMC3612707 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature