Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

ABSTRACT:

Aims

Statins reduce LDL cholesterol (LDL-C) and the risk of vascular events, but it remains uncertain whether there is clinically relevant genetic variation in their efficacy. This study of 18 705 individuals aims to identify genetic variants related to the lipid response to simvastatin and assess their impact on vascular risk response.

Methods and results

A genome-wide study of the LDL-C and apolipoprotein B (ApoB) response to 40 mg simvastatin daily was performed in 3895 participants in the Heart Protection Study, and the nine strongest associations were tested in 14 810 additional participants. Selected candidate genes were also tested in up to 18 705 individuals. There was 90% power to detect differences of 2.5% in LDL-C response (e.g. 42.5 vs. 40% reduction) in the geno

SUBMITTER: Hopewell JC 

PROVIDER: S-EPMC3612775 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature