Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry.

ABSTRACT:

Objective

To characterise pregnancies where the fetus or neonate was diagnosed with fetal and neonatal alloimmune thrombocytopenia (FNAIT) and suffered from intracranial haemorrhage (ICH), with special focus on time of bleeding onset.

Design

Observational cohort study of all recorded cases of ICH caused by FNAIT from the international No IntraCranial Haemorrhage (NOICH) registry during the period 2001-2010.

Setting

13 tertiary referral centres from nine countries across the world.

Participants

37 mothers and 43 children of FNAIT pregnancies complicated by fetal or neonatal ICH identified from the NOICH registry was included if FNAIT diagnosis and ICH was confirmed.

Primary and secondary outcome measures

Gestational age at onset of ICH, type of ICH and cl

SUBMITTER: Tiller H 

PROVIDER: S-EPMC3612794 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature