Calcineurin inhibitor treatment of intravenous immunoglobulin-resistant Kawasaki disease.

ABSTRACT:

Objective

To describe the clinical course and outcome of 10 patients with Kawasaki disease (KD) treated with a calcineurin inhibitor after failing to respond to multiple therapies.

Study design

Demographic and clinical data were prospectively collected using standardized case report forms. T-cell phenotypes were determined by flow cytometry, and KD risk alleles in ITPKC (rs28493229), CASP3 (rs72689236), and FCGR2A (rs1801274) were genotyped.

Results

Intravenous followed by oral therapy with cyclosporine (CSA) or oral tacrolimus was well tolerated and resulted in defervescence and resolution of inflammation in all 10 patients. There were no serious adverse events, and a standardized treatment protocol was developed based on our experiences with this patient population.

SUBMITTER: Tremoulet AH 

PROVIDER: S-EPMC3613150 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature