Ontology highlight
ABSTRACT:
SUBMITTER: Cui L
PROVIDER: S-EPMC3613909 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Cui Lu L Guan Yuan Y Qu Zepeng Z Zhang Jingfa J Liao Bing B Ma Bo B Qian Jiang J Li Dangsheng D Li Weiye W Xu Guo-Tong GT Jin Ying Y
The Journal of clinical investigation 20130325 4
Tumor formation constitutes a major obstacle to the clinical application of embryonic stem cell-derived (ESC-derived) cells. In an attempt to find major extracellular signaling and intrinsic factors controlling tumorigenicity and therapeutic functionality of transplanted ESC-derived retinal progenitor cells (ESC-RPCs), we evaluated multiple kinds of ESC-RPCs in a mouse retinal degeneration model and conducted genome-wide gene expression profiling. We identified canonical WNT signaling as a criti ...[more]