Troponin T, N-terminal pro-B-type natriuretic peptide, and incidence of stroke: the atherosclerosis risk in communities study.

ABSTRACT:

Background and purpose

Increased levels of plasma troponins and natriuretic peptides are associated with increased risk of cardiovascular disease, but only limited information exists on these biomarkers and stroke occurrence. In a prospective epidemiological study, we tested the hypothesis that high-sensitivity troponin T (TnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are associated positively with incidence of stroke.

Methods

The Atherosclerosis Risk in Communities (ARIC) Study measured plasma TnT and NT-proBNP in 10 902 men or women initially free of stroke and followed them for a mean of 11.3 years for stroke occurrence (n=507).

Results

Both biomarkers were associated positively with total stroke, nonlacunar ischemic, and especially cardioembolic s

SUBMITTER: Folsom AR 

PROVIDER: S-EPMC3614093 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature