A gene expression profile test to resolve head & neck squamous versus lung squamous cancers.

ABSTRACT:

Background

The differential diagnosis between metastatic head & neck squamous cell carcinomas (HNSCC) and lung squamous cell carcinomas (lung SCC) is often unresolved because the histologic appearance of these two tumor types is similar. We have developed and validated a gene expression profile test (GEP-HN-LS) that distinguishes HNSCC and lung SCC in formalin-fixed, paraffin-embedded (FFPE) specimens using a 2160-gene classification model.

Methods

The test was validated in a blinded study using a pre-specified algorithm and microarray data files for 76 metastatic or poorly-differentiated primary tumors with a known HNSCC or lung SCC diagnosis.

Results

The study met the primary Bayesian statistical endpoint for acceptance. Measures of test performance include overall

SUBMITTER: Lal A 

PROVIDER: S-EPMC3614454 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature