Genome-wide expression profiling in pediatric septic shock.

ABSTRACT: For nearly a decade, our research group has had the privilege of developing and mining a multicenter, microarray-based, genome-wide expression database of critically ill children (≤10 y of age) with septic shock. Using bioinformatic and systems biology approaches, the expression data generated through this discovery-oriented, exploratory approach have been leveraged for a variety of objectives, which are reviewed here. Fundamental observations include widespread repression of gene programs corresponding to the adaptive immune system and biologically significant differential patterns of gene expression across developmental age groups. The data have also identified gene expression-based subclasses of pediatric septic shock having clinically relevant phenotypic differences. The data have also

SUBMITTER: Wong HR 

PROVIDER: S-EPMC3615026 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature