Dataset Information

Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.

ABSTRACT:

Background and purpose

Determinants of post-acute stroke outcomes in Africa have been less investigated. We assessed the association of metabolic syndrome (MetS) and insulin resistance with post-stroke mortality in patients with first-ever-in-lifetime stroke in the capital city of Cameroon (sub-Saharan Africa).

Methods

Patients with an acute first-stroke event (n?=?57) were recruited between May and October 2006, and followed for 5 years for mortality outcome. MetS definition was based on the Joint Interim Statement 2009, insulin sensitivity/resistance assessed via glucose-to-insulin ratio, quantitative insulin sensitivity check index and homeostatic model assessment.

Results

Overall, 24 (42%) patients deceased during follow-up. The prevalence of MetS was higher in patients who died after 28 days, 1 year and 5 years from any cause or cardiovascular-related causes (all p?0.040). MetS was associated with an increased overall mortality both after 1 year (39% vs. 9%) and 5 years of follow-up (55% vs. 26%, p?=?0.022). Similarly, fatal events due to cardiovascular-related conditions were more frequent in the presence of MetS both 1 year (37% vs. 9%) and 5 years after the first-ever-in-lifetime stroke (43% vs. 13%, p?=?0.017). Unlike biochemical measures of insulin sensitivity and resistance (non-significant), in age- and sex-adjusted Cox models, MetS was associated with hazard ratio (95% CI) of 2.63 (1.03-6.73) and 3.54 (1.00-12.56) respectively for all-cause and cardiovascular mortality 5 years after stroke onset.

Conclusion

The Joint Interim Statement 2009 definition of MetS may aid the identification of a subgroup of black African stroke patients who may benefit from intensification of risk factor management.

SUBMITTER: Balti EV

PROVIDER: S-EPMC3615065 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.

Balti Eric Vounsia EV Kengne André Pascal AP Fokouo Jean Valentin Fogha JV Nouthé Brice Enid BE Sobngwi Eugene E

PloS one 20130402 4

<h4>Background and purpose</h4>Determinants of post-acute stroke outcomes in Africa have been less investigated. We assessed the association of metabolic syndrome (MetS) and insulin resistance with post-stroke mortality in patients with first-ever-in-lifetime stroke in the capital city of Cameroon (sub-Saharan Africa).<h4>Methods</h4>Patients with an acute first-stroke event (n = 57) were recruited between May and October 2006, and followed for 5 years for mortality outcome. MetS definition was ...[more]

PMID: 23565192

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Dataset Information

Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.

Background and purpose

Methods

Results

Conclusion

Publications

Metabolic syndrome and fatal outcomes in the post-stroke event: a 5-year cohort study in Cameroon.

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