Dataset Information

Association of DXA-derived bone mineral density and fat mass with African ancestry.

ABSTRACT:

Context

Both genes and environment have been implicated in determining the complex body composition phenotypes in individuals of European ancestry; however, few studies have been conducted in other race/ethnic groups.

Objective

We conducted a genome-wide admixture mapping study in an attempt to localize novel genomic regions associated with genetic ancestry.

Setting/participants

We selected a sample of 842 African-American women from the Women's Health Initiative single nucleotide polymorphism (SNP) Health Association Resource for whom several dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) and fat mass phenotypes were available.

Methods

We derived both global and local ancestry estimates for each individual from Affymetrix 6.0 data and analyzed the correlation of DXA phenotypes with global African ancestry. For each phenotype, we examined the association of local genetic ancestry (number of African ancestral alleles at each marker) and each DXA phenotype at 570 282 markers across the genome in additive models with adjustment for important covariates.

Results

We identified statistically significant correlations of whole-body fat mass, trunk fat mass, and all 6 measures of BMD with a proportion of African ancestry. Genome-wide (admixture) significance for femoral neck BMD was achieved across 2 regions ∼3.7 MB and 0.3 MB on chromosome 19q13; similarly, total hip and intertrochanter BMD were associated with local ancestry in these regions. Trunk fat was the most significant fat mass phenotype showing strong, but not genomewide significant associations on chromosome Xp22.

Conclusions

Our results suggest that genomic regions in postmenopausal African-American women contribute to variance in BMD and fat mass existence and warrant further study.

SUBMITTER: Ochs-Balcom HM

PROVIDER: S-EPMC3615193 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Publications

Association of DXA-derived bone mineral density and fat mass with African ancestry.

Ochs-Balcom Heather M HM Preus Leah L Wactawski-Wende Jean J Nie Jing J Johnson Nicholas A NA Zakharia Fouad F Tang Hua H Carlson Chris C Carty Cara C Chen Zhao Z Hoffman Thomas T Hutter Carolyn M CM Jackson Rebecca D RD Kaplan Robert C RC Li Li L Liu Song S Neuhouser Marian L ML Peters Ulrike U Robbins John J Seldin Michael F MF Thornton Timothy A TA Thompson Cheryl L CL Kooperberg Charles C Sucheston Lara E LE

The Journal of clinical endocrinology and metabolism 20130222 4

<h4>Context</h4>Both genes and environment have been implicated in determining the complex body composition phenotypes in individuals of European ancestry; however, few studies have been conducted in other race/ethnic groups.<h4>Objective</h4>We conducted a genome-wide admixture mapping study in an attempt to localize novel genomic regions associated with genetic ancestry.<h4>Setting/participants</h4>We selected a sample of 842 African-American women from the Women's Health Initiative single nuc ...[more]

PMID: 23436924

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Dataset Information

Association of DXA-derived bone mineral density and fat mass with African ancestry.

Context

Objective

Setting/participants

Methods

Results

Conclusions

Publications

Association of DXA-derived bone mineral density and fat mass with African ancestry.

Similar Datasets

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