Association of DXA-derived bone mineral density and fat mass with African ancestry.

ABSTRACT:

Context

Both genes and environment have been implicated in determining the complex body composition phenotypes in individuals of European ancestry; however, few studies have been conducted in other race/ethnic groups.

Objective

We conducted a genome-wide admixture mapping study in an attempt to localize novel genomic regions associated with genetic ancestry.

Setting/participants

We selected a sample of 842 African-American women from the Women's Health Initiative single nucleotide polymorphism (SNP) Health Association Resource for whom several dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) and fat mass phenotypes were available.

Methods

We derived both global and local ancestry estimates for each individual from Affymetrix 6.0 data an

SUBMITTER: Ochs-Balcom HM 

PROVIDER: S-EPMC3615193 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature