Comparative effectiveness of screening and prevention strategies among BRCA1/2-affected mutation carriers.

ABSTRACT:

Unlabelled

Comparative effectiveness research has become an integral part of health care planning in most developed countries. In a simulated cohort of women, aged 30-65, who tested positive for BRCA1 or BRCA2 mutations, we compared outcomes of mammography with and without MRI, prophylactic oophorectomy with and without mastectomy, mastectomy alone, and chemoprevention.

Methods

Using Treeage 9.02 software, we developed Markov models with 25,000 Monte Carlo simulations and conducted probabilistic sensitivity analysis. We based mutation penetrance rates, breast and ovarian cancer incidence, and mortality rates, and costs in terms of 2009 dollars, on published studies and data from the Surveillance, Epidemiology, and End RESULTS (SEER) Program and the Centers for Medicare and M

SUBMITTER: Grann VR 

PROVIDER: S-EPMC3615889 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature