In silico approaches for designing highly effective cell penetrating peptides.

ABSTRACT:

Background

Cell penetrating peptides have gained much recognition as a versatile transport vehicle for the intracellular delivery of wide range of cargoes (i.e. oligonucelotides, small molecules, proteins, etc.), that otherwise lack bioavailability, thus offering great potential as future therapeutics. Keeping in mind the therapeutic importance of these peptides, we have developed in silico methods for the prediction of cell penetrating peptides, which can be used for rapid screening of such peptides prior to their synthesis.

Methods

In the present study, support vector machine (SVM)-based models have been developed for predicting and designing highly effective cell penetrating peptides. Various features like amino acid composition, dipeptide composition, binary profile of p

SUBMITTER: Gautam A 

PROVIDER: S-EPMC3615965 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature