Effects of mechano-electric feedback on scroll wave stability in human ventricular fibrillation.

ABSTRACT: Recruitment of stretch-activated channels, one of the mechanisms of mechano-electric feedback, has been shown to influence the stability of scroll waves, the waves that underlie reentrant arrhythmias. However, a comprehensive study to examine the effects of recruitment of stretch-activated channels with different reversal potentials and conductances on scroll wave stability has not been undertaken; the mechanisms by which stretch-activated channel opening alters scroll wave stability are also not well understood. The goals of this study were to test the hypothesis that recruitment of stretch-activated channels affects scroll wave stability differently depending on stretch-activated channel reversal potential and channel conductance, and to uncover the relevant mechanisms underlying the obs

SUBMITTER: Hu Y 

PROVIDER: S-EPMC3616032 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature