PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.

ABSTRACT: Epithelial ovarian cancer is a heterogeneous disease that is subdivided into five major histotypes but the mechanisms driving their differentiation are not clear. Mutations in adenomatous polyposis coli (APC) and β-catenin are commonly observed in the human ovarian endometrioid adenocarcinoma (OEA) patients. However, the mechanisms subsequent to APC deletion in ovarian tumorigenesis have not been well characterized. We have conditionally deleted APC in the murine ovarian surface epithelium (OSE) and showed that its loss leads to development of epithelial inclusion cysts. High-grade OEAs with tightly packed villoglandular histology were observed in older APC-deleted mice. Phosphatase and tensin homolog (PTEN) expression was elevated in the early lesions but lost after progression to the mor

SUBMITTER: Tanwar PS 

PROVIDER: S-EPMC3616672 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature