Interaction of cigarette smoking and carcinogen-metabolizing polymorphisms in the risk of colorectal polyps.

ABSTRACT: The causal role of cigarette smoking in the risk of colorectal neoplasm has been suggested but not established. In a case-control study including 2060 colorectal polyp patients and 3336 polyp-free controls, we evaluated 21 functional genetic variants to construct a tobacco-carcinogen-metabolizing genetic risk score. Data regarding cigarette smoking were obtained through telephone interviews. Cigarette smoking was associated with an elevated risk of both adenomas and hyperplastic polyps. The association with smoking was stronger in participants with a high carcinogen-metabolizing risk score than those with a low risk score. Smoking 30 or more cigarettes per day was associated with a 1.7-fold elevated risk of any polyps (95% confidence interval = 1.3-2.2) among those with a low genetic risk

SUBMITTER: Fu Z 

PROVIDER: S-EPMC3616674 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature