IRSpot-PseDNC: identify recombination spots with pseudo dinucleotide composition.

ABSTRACT: Meiotic recombination is an important biological process. As a main driving force of evolution, recombination provides natural new combinations of genetic variations. Rather than randomly occurring across a genome, meiotic recombination takes place in some genomic regions (the so-called 'hotspots') with higher frequencies, and in the other regions (the so-called 'coldspots') with lower frequencies. Therefore, the information of the hotspots and coldspots would provide useful insights for in-depth studying of the mechanism of recombination and the genome evolution process as well. So far, the recombination regions have been mainly determined by experiments, which are both expensive and time-consuming. With the avalanche of genome sequences generated in the postgenomic age, it is highly desi

SUBMITTER: Chen W 

PROVIDER: S-EPMC3616736 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature