Associations between selected immune-mediated diseases and tuberculosis: record-linkage studies.

ABSTRACT:

Background

Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB).

Methods

We analyzed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999 to 2011), and a similar database (the Oxford Record Linkage Study (ORLS)) for a region of southern England in an earlier period. Rate ratios for TB were determined, comparing immune-mediated disease cohorts with comparison cohorts.

Results

In the all-England dataset, there were significantly elevated risks of TB after hospital admission for the following individual immune-mediated diseases: Addison's disease, ankylosing spondylitis, autoimmune hemolytic anemia, chronic active hepatitis, coe

SUBMITTER: Ramagopalan SV 

PROVIDER: S-EPMC3616814 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature